Live coverage of the milestone event will begin in the stream above at around 6.30AM ET, with the spacewalk itself scheduled to start 8AM and continue for six-and-a-half hours.
During preparations earlier in the morning, a small amount of water leaked from the connection point between an umbilical hose and Fischer's suit. That delayed things for a couple hours.
Despite the delays, first time spacewalker Fischer seemed to enjoy the views.More news: Absolver Launches on August 29 for PS4 & PC
Fischer has never spacewalked before. According to NASA, the duo will "replace a large avionics box that supplies electricity and data connections to the science experiments", and make some preparations for an global docking port.
"Outstanding, Peggy", came the voice from Houston's Mission Control.
Fischer ended up sharing Whitson's spacesuit servicing system, which caused both to burn through their spacesuits' battery power faster than usual.
Whitson and Fischer proved them wrong.More news: IPhone 7 lineup accounts for 11% of world's smartphone market in Q1
And Fischer installed some thermal insulating over on the Japanese robotic arm.
Spacewalkers have now spent a total of 1,247 hours and 55 minutes working outside the station during 200 spacewalks in support of assembly and maintenance of the orbiting laboratory. In the first mission, Ross and Newman attached out outfitted the first two components of the station, NASA reports.
CAPE CANAVERAL, Fla. (AP) An equipment water leak shortened Friday's spacewalk by two US astronauts at the International Space Station.
And there were actually two records set 250 miles above us on Friday. This is also the 9th time Whitson has taken part in a spacewalk, extending her record as the American woman with the most spacewalks in history.More news: 25 great white sharks spotted off Southern California coast
Phil Keating joined Fox News Channel (FNC) in March 2004 and now serves as FNC's Miami-based correspondent.