The 50 Premier League matches between these sides so far have mustered an average of 2.76 goals per game, and it is fairly likely that the strikes will flow - at least for the hosts.
Mourinho believes that a legend's welcome should be on the cards for the Englishman, who is in line to feature despite his personal life coming into focus in recent weeks.
The United legend told Sky Sports News: "If you score a goal, you hear players talk about, you sort of lose yourself and I don't think we should get away from that".More news: Oil prices rise as IEA sees higher demand, shrinking inventories
Atalanta director Umberto Marino admits "just qualifying for Europe was a huge achievement, but we keep riding the wave of enthusiasm" with Everton.
"I think you've seen past year what he's capable of and what he did for Everton - he scored a lot of goals - and now he's carrying that form on which is great for us", he said.
He had been restricted to just 15 Premier League starts in his final campaign, during which he broke the club's goal scoring record.More news: Direct Line Insurance Group Shares Recommendation Reiterated by Goldman Sachs Group,
"But there is a lot of quality to the player, and a lot of quality around him".
"They're waiting for a real chance to start matches and to play from the beginning".
What they subsequently delivered prompted plenty of boos from Everton fans who had travelled to the Mapei Stadium, and when asked in his post-match press conference if he shared the supporters' anger, the Dutchman said: "Yes of course".
"I think he comes [to United] in the right moment, [he is] a good age, a good number of years of experience in different clubs in the Premier League and clearly a player adapted to the Premier League with good friends already in this dressing room. I don't want to make it individual because it's a team performance, but we need to be more aggressive". Our whole gameplan last season was to play to Lukaku's strengths and Calvert-Lewin is bloody big too. We had a bad run last season, we came out of that, and I have confidence we can get out of this run.More news: Barrasso: Sanders' Healthcare Plan 'a Nice Slogan,' But a Bad Idea