The Buckeyes ran nine offensive plays in the first quarter for a total of minus-6 yards - the first time they have had negative yards in a quarter under head coach Urban Meyer. The Wolverines also finish the regular season without beating a team with a winning record.
The stars aligned for MI to finally get off the snide against Ohio State.
Barrett almost threw an interception inside the 10-yard line and had a touchdown taken off the board because of a delay-of-game penalty, but he found a way to overcome those struggles and score Ohio State's first touchdown of "The Game" against the Wolverines.
But things began to slip from there.
Red-shirt freshman Dwayne Haskins Jr. led the Buckeyes right down the field to give Ohio State the lead and the eventual win, 31-20.More news: Pakistan summons army after violent protests
Karan Higdon's 2-yard run gave MI (8-4, 5-4) a 20-14 lead midway through the third quarter.
Meyer was unsure of Barrett's status heading into the Big Ten title game against Wisconsin next weekend.
Haskins came in and converted six of his first eight third-down attempts.
O'Korn was picked off by safety Jordan Fuller on the next play, and Mike Weber's 25-yard touchdown run with 1:44 left clinched the Ohio State victory.
Barrett has totaled more than 11,000 yards and 142 touchdowns combined rushing and passing in his career.More news: Dish Network urges customers to bug advertisers over CBS blackout
Michigan's backup quarterbacks Saturday are Alex Malzone, Michael Sessa and freshman Dylan McCaffrey, son of former National Football League player Ed McCaffrey and brother of Carolina Panthers running back Christian McCaffrey.
The Wolverines had a litany of small mistakes Saturday that all added up to loom large.
Initially, Ohio State took possession of the ball on a punt with a modest return.
Then, Ohio State faced a third-and-three from Michigan's 43-yard line. For the Wolverines, it'll sting for another year.More news: You are what you drink