Romero, who rescued the main event by stepping in to replace the injured Robert Whittaker some weeks ago, missed championship weight on Friday to leave himself ineligible for the interim middleweight title strap.
Here's a look at the key talking points from UFC 221.
In the early hours of Sunday morning, the UFC will hold its second pay-per-view event of the year. Stunned, Rockhold looked to clinch up but Romero simply began obliterating his midsection with hooks.More news: Omarosa leaves 'Celebrity Big Brother' house for medical attention
Last night, in the main event of UFC 221, former Olympic wrestler Yoel Romero picked up one of the best wins of his awesome career thus far, knocking out former UFC and Strikeforce champion Luke Rockhold with a brutal, third-round salvo.
But the massive Cuban will get the opportunity to fight for the only belt that matters after knocking out Rockhold with two crushing left hands.
The pair traded vicious leg kicks throughout the first round, with Rockhold bleeding from his shin and Romero walking with a noticeable limp. UFC President Dana White told ESPN.com's Brett Okamoto that Romero is still expected to receive the next 185-pound title shot against Whittaker down the road.
"Rockhold is a very good athlete and an awesome fighter", Romero said after the fight.More news: Indian PM arrives in Ramallah for talks with Abbas
Shortly after Romero's win, Whittaker took to Twitter to congratulate his rival in his own language. For Romero, a win here would also set him up nicely for another shot at the belt.
The fireworks came just before that bout though, when two more unknown heavyweights in Tai Tuivasa and Cyril Asker battled it out.
But the 26-year old American played it wisely and changed things up, taking Hunt down to the canvas, where the two spent most of the remainder of the fight as Blaydes superior fitness eventually told, the judges scoring it 30-26, 30-26 and 29-27 in the U.S. fighter's favour.
As it turns out, the Western Australia Combat Sports Commission doesn't release the names of the judges scoring the fights at ringside or provide a breakdown of how they scored each frame.More news: Policeman killed, two wounded in Georgia shooting