Scotland were without a win over the Auld Enemy since 2008 but handing England just their second defeat of Eddie Jones' tenure has sparked fresh hope they can mount a NatWest 6 Nations title challenge.
A 37-27 win over Wales in Dublin which secured a try bonus point and put them five points clear at the head of the Championship after Scotland shocked England at Murrayfield.
This was just England's second defeat in 26 Tests under Eddie Jones, whose ultimate aim with is to win next year's World Cup.
Full credit to Scotland.
Jones repeatedly denied knowledge of what had taken place, as did every player from both teams when asked for their version of events.
"It's definitely going to be tough for the last couple of games but if we keep performances up like that we've got a chance".More news: Jonathan Martin being held in mental health facility after threatening post
"It's human nature, unfortunately we just weren't in the game for the first 40 minutes". That's disappointing. I have got take responsibility for the performance because we weren't there.
'These lessons you don't want to have but they are the best lessons in the world.
England thought they were about to score their second try when Care intercepted a loose pass from opposing scrum-half Laidlaw but referee Nigel Owens penalised England lock Joe Launchbury for slowing the ball at the preceding ruck.
"They are such a great team so to have the trophy in the dressing room after such a great game and to have Murrayfield as epic as it was today is something I'll remember". I have to work out what I did wrong and work out how to fix it.
"We were ready, it's a Calcutta Cup with 140 years of history".
Scotland captain John Barclay had backed Russell to come good against arch-rivals England in the latest edition of rugby's 147-year-old foundation global fixture. We knew the significance and we knew what would get thrown at us at Murrayfield but we weren't good enough to handle it and I apologise.More news: Korean 'Iron Man' Kim wins historic Olympic skeleton gold
England came out for the second half 22-6 down - its largest halftime deficit in 136 meetings against Scotland - and scored its only try nearly immediately through center Owen Farrell.
Six Nations organisers are certain to investigate the incident and photographs confirm it took place, but Jones was unaware of what had happened.
"I've been coaching a game".
"I can't get my head around this "finishing" business", said the former England and British and Irish Lions centre. Are you aware of it?
"I think for a 10 to be world class you've got to have the boys around you that help you out, and today everyone played so well", he said. I know what's happening. If there was, we shouldn't let that detract from a great Scotland victory. "Don't get distracted by other things". Scotland captain John Barclay said he was in the toilet at the time.
I don't know how much of it's true or what happened.More news: Pentagon Will Not Confirm Russian Stealth Fighters Deployed to Syria