The flight, dubbed QF9, will run daily.
'This is a truly historic flight that opens up a new era of travel.
The UK's longest non-stop regular passenger flight will set off back for Perth at 1.15pm on Sunday.More news: American family of 4 found dead during Mexico vacation inhaled 'toxic gases'
The flight takes 17 hours, that's a massive leap since the original so-called Kangaroo route in the 1940's that saw the flight stop at seven stopovers, taking four days.
Meanwhile, Qantas has challenged Airbus and Boeing to produce an aircraft capable of flying direct from Sydney and Melbourne to London and NY.
Joyce added: "It's great news because it will bring us closer to one of our biggest trade partners and source of visitors".
If both can manage the range, Qantas will call for tenders next year and place an order, with the aircraft likely to be ready by 2022.More news: U.S. sends China to-do list to reduce trade imbalance
"We've recently announced the reconfiguration of the A380, there will be many elements of that which will be aligned with the Dreamliner so it means that we know that we've done things that are working well with customers and now we are going to continue to roll those our across the rest of the worldwide fleet". The Boeing 787-9 Dreamliner completed the 9,226-mile journey eight minutes ahead of schedule.
"That might be the distinction where ultra-long-haul non-stop becomes the preserve of the senior exec or those who maybe have more time-critical business", Johnson said.
The inaugural flight coincided with the opening of the airline's new Perth International Transit Lounge featuring special lighting created to reduce jetlag, as well as pre-flight stretching classes, and relocating all of the airline's domestic and international flights into a single terminal at Perth Airport for faster, smoother connections. Inside Qantas' ground-breaking Dreamliner business class cabinThe stuff flying dreams are made of. Qantas' CEO Alan Joyce says the airline has combatted this by putting "hands-down the most comfortable aircraft that Qantas has ever put in the sky".
The aircraft boasts a number of advantages over other models, including lower cabin noise, larger windows, improved air quality and technology to reduce turbulence.More news: Catalan leader Carles Puigdemont held by German police