The Spaniard didn't face a break point in his match against Dzumhur, who won his sole game after dropping the first five of the first set. Unfortunately for the Italian, he has lost their five meetings since that win, although he did manage to take a set off Nadal in Madrid past year. "I think this was probably one of the three matches that I played this way in the past 12 months".
Nadal lost his first match on clay in over a year last week in the Madrid quarter-finals to Austrian Dominic Thiem and as a result lost his world number one ranking to Roger Federer. I don't know how many mistakes I made, but not many. But with my serve, I didn't lose many points.
The Spaniard will resume his quest for his first title in Rome in five years against Italian Fabio Fognini. "I hope in Paris I will have a little bit longer time to come into the tournament".
Djokovic will play Albert Ramos-Vinolas, who rallied past eighth-seeded John Isner 6-7 (5), 7-6 (2), 7-6 (5).
Nadal will next face Canada's Denis Shapovalov, who faced a grueling test in battling past Dutchman Robin Haase 7-6 (3), 6-7 (5), 6-3 in almost two and a half hours.More news: Ebola cases on rise, reach 14 in DRC
Seeking an 8th Rome title, ahead will be Italian bad boy Fabio Fognini who bested Peter Gojowczyk 6-4, 6-4.
Defending champion Alexander Zverev won his 11th straight match but had to work really hard to beat Kyle Edmund needing eight match points in the second set tiebreaker to win it 7-5, 7-6 (11).
Third seed Grigor Dimitrov did not have a birthday to remember as he fell 7-6 (4), 5-7, 4-6 to Kei Nishikori.
Cilic will play 10th-seeded Pablo Carreno Busta, who beat Aljaz Bedene 6-4, 6-7, 6-2.
A year ago in Rome, Halep rolled her ankle in the final and lost a lead and the championship to Elina Svitolina.More news: Metro Exodus delayed, won't see light of day until Q1 2019
Halep needs to reach at least the quarterfinals or risk losing the top spot to Caroline Wozniacki.
The victor will play Anett Kontaveit, who ousted 1999 champion Venus Williams 6-2, 7-6 (3).
Although six seeded players suffered exits on Wednesday (May 16), Juan Martin del Potro and Marin Cilic were able to advance.
Kontaveit, who also beat Williams last week in Madrid, next plays either second seed Wozniacki or Latvia's Anastasija Sevastova for a place in the semi-finals.
Fourth seed Elina Svitolina of Ukraine recovered from a stunning 6-0 first set loss to Russia's Daria Kasatkina to take the match following 6-3 and 6-2 wins in the second and third sets respectively.More news: Dirty Jokes Found in Anne Frank's Diary