Sharif's wife was diagnosed with lymphoma (throat) cancer in August 2017, and since then she was receiving treatment.
Begum Kulsoom had contested and won NA-120, a traditional bastion of the Pakistan Muslim League (Nawaz) after the seat fell vacant following Nawaz Sharif's disqualification by the Supreme Court (SC) in the Panama Papers case.
Army Chief Gen. Qamar Jawed Bajwa also expressed grief over Kulsoom's death and extended condolences to her family.
Kulsoom Nawaz, the wife of former prime minister Nawaz Sharif died at the age of 68 on Tuesday in London, months after a cardiac arrest put her to Intensive Care Unit (ICU).More news: Aaron Rodgers Leaves Game Injured, Then Returns To Lead Stunning Comeback
She was placed on life support earlier today as her health deteriorated last night. A slight improvement in her condition was reported by her family members in June, a day before her husband and daughter were sent to prison reported Dawn.
Up until her husband's ousting past year, Kulsoom Sharif had never been a politician, but she memorably led protests after a 1999 military coup that ended a previous Sharif administration.
They are now serving jail terms of 10 and seven years, respectively, at Rawalpindi's Adiala jail, as well as being fined $10.5m and $2.6m each.
He has directed the Pakistani High Commission in London to assist in provision of all necessary facilities to the heirs of the deceased.More news: Tropical Storm Florence continues its churn toward USA coast
Both sons Hassan and Hussain reside in the United Kingdom and cared for her while Nawaz and Maryam attended near daily hearings of their corruption trial. The father and daughter will be granted parole to attend her last rites. She was diagnosed with lymphoma a year ago, barely a month after Nawaz Sharif was removed from office by the Supreme Court, which ordered him to face trial in an anti-corruption court.
Since then, Nawaz and Maryam have been making regular making trips to the United Kingdom to visit Kulsoom.
Begum Kulsoom Nawaz leaves behind daughters four children, Asma, Maryam, Hasan and Hussain. She was diagnosed with lymphoma a year ago.
She attended Islamia College and graduated from the Forman Christian College in Lahore before completing her masters in Urdu from Punjab University in 1970. And when he was arrested by the Musharraf regime in the 1999 coup, she spearheaded the campaign for his release. Maryam had said in the past that her mother "dauntlessly challenged the usurper (Pervez Musharraf) when a lot of men backed out. May Allah bless the departed soul eternal peace at Heaven-Amen", the director general of Inter-Services Public Relations said in a message.More news: Donald Trump Jr. 'fixes' Kaepernick Nike ad with his dad's face