In the end, the award went to Game of Thrones, which also won an Emmy via Peter Dinklage earlier in the night. "Maisel" became the first show from a streaming service to win best comedy, while HBO's "Game of Thrones" was the top drama.
Bill Hader collected the best comedy actor award for "Barry", a dark comedy about a hired killer who stumbles into a possible acting career.
Brosnahan's castmate Alex Borstein earned the supporting actress trophy and the series creator, Amy Sherman-Palladino ("Gilmore Girls"), nabbed writing and directing awards.
Netflix began to dominate the Emmys conversation back in July when, for the first time ever, the streamer surpassed HBO to grab 112 nominations and break the premium cable channel's 17-year streak of being the most-nominated network.More news: Tom Arnold Claims Mark Burnett Attacked Him at Pre-Emmy Party
Saturday Night Live won, as expected, for variety sketch series, taking its lifetime Emmy total to a record-setting 72 wins.
The third season of Netflix's true-crime anthology documented Versace's murder by Criss's Andrew Cunanan, with its director Ryan Murphy winning the award for Outstanding Directing for a Limited Series, Movie or Dramatic Special for the first episode of the season, "The Man Who Would be Vogue".
Henry Winkler, aka "The Fonz", won a supporting actor award for "Barry", four decades after gaining fame for his role in "Happy Days".More news: 'Relentless rains' continue as Florence almost stalls over Carolinas
Thandie Newton also won in the supporting actress in a drama series category for Westworld, but some of the actors of color for whom hopes were highest - Sandra Oh in Killing Eve, for instance - they didn't come to pass.
"Game of Thrones" is back and led the nominations with 22 nods, including outstanding drama against last year's victor, "The Handmaid's Tale". Emmy victor Glenn Weiss heartened audience members by proposing to his girlfriend while onstage accepting an award for directing the Oscars telecast.
As a effect, the breezy tone and ebullient moments - which began with a promising song-and-dance number about strides in diversity within the TV industry, cheekily titled "We solved it" - gave way to lethargy and clunky ones. "Talk to your closest black friend and ask them to explain it to you", he says he told her, according to the Globe.
Betty White, 96, thanked the industry for putting up with her.More news: 'Trying to attack me': Kavanaugh accuser reveals details of alleged sexual misconduct