The losing team will go on to play in the one-game National League Wild Card game, with the victor getting a few days off before advancing to the NL Division Series.
It was just the 15th and 16th times in Major League Baseball history that a 163rd game was needed in order to decipher a division victor. First pitch is 3:15 p.m. on FS1.More news: Amazon raises pay for hundreds of workers in Peterborough
This is the second time that each franchise has played in the Wild Card Game.
The losers will be relegated to the Wild Card game, while the winners will be crowned division champions and get a few more days off before the best-of-five postseason starts later in the week.
Nationally, according to Nielsen's overnight ratings of the metered markets, the twin National League tiebreakers of Cubs-Brewers and Dodgers-Rockies scored ESPN's two highest-rated MLB regular-season afternoon telecasts in 20 years. Both clubs landed in the Wild Card Game after losing a Game 163 tiebreaker on Monday. They're focused on the Lester with the Cubs now - and lately he's been very good.More news: Cardi B questioned by police over strip club fight
In the Central, the Brewers blanked the Detroit Tigers 11-0 for their 95th win of the season against 67 losses. After finishing off the Washington Nationals on Sunday at Coors Field, the Rockies left for California.
It's a criss-cross kind of trip and it's one that the Rockies hoped they weren't going to have to make.More news: Zidane's surprising phone call to Man United coach Mourinho