Messi scored twice, played a major role in Barca's other goals and hit the post twice as Tottenham slipped to back-to-back defeats in Group B.
On the first match back at Wembley Stadium since Anthony Joshua defeated Alexander Povetkin, the portion of the pitch given over to the general area inhabited by the boxing ring appeared to be far from what one would normally expect of Spurs' adopted home.
However, while those moments encapsulated Messi's individual brilliance, his ruthless streak was showcased shortly afterward when, with the score 2-1, he finished off a move of beauty to restore Barcelona's two-goal advantage.More news: Matic: Man Utd don't need crisis talks; leaders do it on pitch
But Barcelona needed the mercurial Messi at his best to repel a tenacious Spurs fightback as Harry Kane and Erik Lamela gave the hosts, described as "heroes" by their manager Mauricio Pochettino, a glimmer of hope. "When you play against Barcelona you can have different players and different tactics but the result will be the same".
For Barcelona's opening goal, MESSI played a ball from deep in midfield which cut through the Tottenham back line to find Jordi ALBA. If you watch the first half again, how many chances did he have?More news: Netflix might make a choose-your-own-adventure 'Black Mirror'
Tottenham fought hard, just as Manchester United tried in the 2011 Champions League final, but Messi was simply too elusive, too good.
The report added that Gerard Pique criticized Messi for not facing the media about the club in Barcelona but only when he is in Argentina. Catch live scores and updates of the Champions League match between Tottenham Hotspur and Barcelona here.
"He set the standard, he and Cristiano Ronaldo have gone above the normal standard, when they are scoring 50 or 60 goals a season", Kane said on Tuesday.More news: Atletico visit Real in key Madrid derby on Saturday
"To concede a goal so early, we destroyed the plan", he said. "We had a few problems during the game but we managed to solve them". We need to produce that same energy, the crowd were fantastic that night.