"We have to think about what it would mean if Judge Kavanaugh were to be confirmed to the Supreme Court with credible sexual assault allegations against him", Durbin said from the Senate floor on Friday.
Kavanaugh is expected to be sworn in quickly and will join four liberal justices and four other conservatives as the court, which is expected soon to hear controversial disputes involving abortion, immigration, gay rights and voting rights.
The final vote was 50-48, nearly completely down party lines with Sen. Joe Manchin of West Virginia became the final formerly undecided senators to announce their votes.
She later clarified she was "not making any announcements" but was "deeply disappointed in Senator Collins's vote for Kavanaugh".
Friday's "cloture" vote - 51-49 in favour - was a test of support for the embattled nominee who has faced sexual assault allegations from several women, including Prof Christine Blasey Ford.
On Thursday, about 300 protesters, including sexual assault victims, were arrested after staging demonstrations on Capitol Hill opposing Kavanaugh, chanting "Believe survivors".More news: US Senate heads to final vote on Kavanaugh Supreme Court nomination
That response will likely be scrutinized even further with the November 6 midterm elections a month away, giving Democrats have a chance take control of one or more chambers of Congress.
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Judge Kavanaugh denied the claim - and allegations that he drank to the point of memory loss at the time - in a feisty confrontation with senators. The Senate is likely to vote late Saturday. That left unclear whether Friday's tally signaled that the 53-year-old federal appellate judge was on his way to the nation's highest court.
President Barack Obama's former National Security Adviser Susan Rice has already indicated she wants to run against Collins, although she later added, "many thanks for the encourgement (sic)". A final confirmation vote could come as early as Saturday.
Meanwhile hundreds of people protested outside the US Capitol against Kavanaugh. Murkowski then would announce how Daines would have voted and that she voted the opposite way "and that they therefore withdraw their vote and are instead recorded as present", Stewart said. "The times they are a'changin", she said.More news: Heads Up! Strong-armed fan hits Yanks’ Stanton with HR ball
Before Vice President Mike Pence called for the first vote, protesters in the Senate angrily began yelling and were dragged out of the chamber by police.
One of those women, Debbie Ramirez, a classmate of Kavanaugh's at Yale University in the 1980s, issued a statement on Saturday saying that as she watched the Senate debate, "I feel like I'm right back at Yale where half the room is laughing and looking the other way". But one by one, they let their positions be known.
"I'm a patriot", another said.
The president himself was calling senators, engaging senators throughout the week, but also today.
All but one Republican lined up behind him, arguing that a truncated FBI investigation turned up no corroborating witnesses and that Kavanaugh had sterling credentials for the court.
4, just over a month ago, but it feels like an eternity - before the country was convulsed by accusations of sexual assault against the Supreme Court nominee, now on the brink of becoming the nation's 114th justice.More news: Theresa May Beats Back Her Critics Over Brexit