Kavanagh has denied the abuse accusations.
Friday's vote concerned issues that "are bigger than the nominee" and are necessary for fully functioning legislative and judicial branches, Murkowski said.
It would be a cruel irony if Manchin voted for Kavanaugh and helped save his nomination while a Republican, Murkowski, voted against him, but given that he is up for reelection in a state where Trump remains popular, it is a distinct possibility.
Republican Senator Susan Collins and Joe Manchin, a Democrat, both indicated their backing for the judge on Friday. Former Alaska governor and Republican vice presidential Sarah Palin nominee, a long-time political foe of the Murkowski family, suggested she might challenge the incumbent senator when she's up for re-election.
The other senators who have been closely watched since it was not known how they would vote - Republican Sen.More news: Washington senators voice opposition to Kavanaugh confirmation on Senate floor
Brett Kavanaugh's path to the US Supreme Court is all but assured after two senators said they will elect the conservative to the country's highest court. She said on the Senate floor Friday evening that Kavanaugh is "a good man" but his "appearance of impropriety has become unavoidable".
Mr Kavanaugh's nomination was left teetering on the edge after university psychology professor Christine Blasey Ford claimed in harrowing testimony last week that he tried to rape her when they were high school students.
She made the remarks hours after Sen.
Kavanaugh's confirmation vote is scheduled to begin at 3:30 p.m. on Saturday.
A key procedural vote Friday morning passes with a simple majority and that starts the clock for a final confirmation vote on judge Brett Kavanaugh to happen by Saturday afternoon, October 6 at around 5 p.m.
"I don't think she has any regrets", Banks said.More news: Pompeo to travel to N.Korea, meet Kim
Senator Collins ended hopes she would side with her Democratic colleagues in the final vote, telling senate colleagues she did not believe the "charges can fairly prevent Judge Kavanaugh from serving on the court".
Republicans control the Senate by a 51-49 margin, and Saturday's roll call vote seems destined to be almost party-line, with just a single defector from each side.
They protested after an Federal Bureau of Investigation report which Republicans say exonerates him of sexual assault claims, with Democrats complaining it is too limited.
The Friday cloture vote limits further debate and Democrats' ability to filibuster the final vote.
"Very proud of the U.S. Senate for voting "YES" to advance the nomination of Judge Brett Kavanaugh!".
Sen. Susan Collins (R-ME) voted "Yes" on cloture and is a rumored "Yes" on the final vote.More news: China spying on Apple, Amazon and over 20 other companies