In addition to the jackpot victor, the sales frenzy produced a whopping 36 second prize tickets - each matching the five white balls drawn Tuesday night.
If no tickets matched the Tuesday numbers, lottery officials said the jackpot was expected to grow to an estimated $2 billion for Friday's drawing.
There has not been a Mega Millions ticket sold with "all six numbers" matching the drawing since July 24, allowing the jackpot to roll over for 13 consecutive weeks and the prize to swell.
Jackpot winners can remain anonymous in eight states - Delaware, Georgia, Kansas, Maryland, North Dakota, Ohio, South Carolina and Texas.
The games are played in 44 states, Washington, D.C., and the U.S. Virgin Islands.More news: 'We've paid a big price': Australia government loses crucial by-election
One winning ticket was apparently sold for the world record $1.6 million Mega Millions jackpot.
Odds of winning the prize were 1 in 302 million.
Even if you didn't win the Mega Millions, you still have a shot at the Powerball.
Mega Millions needs to change its name as it's no longer accurate.
Of course, whoever wins the prize won't be able to turn in a ticket and be handed $1 billion in cash.
The lump sum cash payout is estimated at $354.3m.More news: Egypt says actions "decisive and brave" by Saudi over missing journalist case
This amount of money is the most to be won in the history of the Mega Millions.
Gordon Medenica, lead director of the Mega Millions Group, said: "The moment we've been waiting for finally arrived and we couldn't be more excited".
Including the jackpot and lesser prizes, there were 15.75 million tickets Tuesday night that earned bettors at least the face value of the ticket.
And if you find that you are not mega-lucky from Tuesday night's drawing, there's always Powerball.
Don't worry if you weren't the lucky Mega Millions victor.
Powerball has climbed since there was a victor in NY on August 11.More news: Hamilton grabs pole position at US GP
Although Tuesday's jackpot was extraordinarily large, it's no fluke.