But perhaps the biggest overall impact to air travelers was in Chicago, where more than 790 combined arrivals and departures had been canceled as of 10:20 p.m. ET at the city's busy O'Hare airport.
"It's going to be messy", said Todd Kluber, a meteorologist for the National Weather Service who is based in suburban Chicago.
The National Weather Service has issued a blizzard warning for parts of Nebraska, Kansas, Missouri and Iowa. At Kansas City International Airport, almost 200 flights were canceled.
Holiday travelers were already facing delays and cancellations at both of the city's airports as the storm pushed into the area.
Many major airlines were waiving change fees. The heavy snow and strong winds across the Midwest are expected to cause whiteout conditions, which can affect visibility, causing unsafe travel.More news: Teargas fired on migrants as United States agents close Mexico border crossing
More outages will be possible as the storm intensifies through the afternoon, the National Weather Service warned.
Preliminary data from the NWS says different parts of the state received between 2 to 12 inches of snow.
The metro area saw a windy morning Sunday as snow moved through the area and temperatures fell. That included semitrailer trucks jackknifed across the highway.
Governor Jeff Colyer is declaring a State of Disaster Emergency in response to Sunday's winter storm.
In Iowa, travel wasn't advised on Interstate 29 from about Pacific Junction south into Missouri.More news: Turkey rips Trump for turning a "blind eye" to Jamal Khashoggi killing
With up to a foot of snow expected to fall in the northwestern part of the city and suburbs, the storm could break a 123-year-old record for biggest snowstorm in Chicago in November.
Visibility will be reduced and 3 to 4 inches of snow could fall in parts of central and northern Kansas.
Mesoscale Discussion 1662 NWS Storm Prediction Center Norman OK 0357 PM CST Sun Nov 25 2018 Areas affected.Northeast Missouri.far southeast Iowa.portions of western Illinois Concerning.Blizzard Valid 252157Z - 260200Z SUMMARY.Rain/wintry mixed precipitation across the area is expected to transition to snow with eastward progression of the surface low.
By Monday morning, the storm was expected to hit parts of northern IN and southern MI.
Expect travel difficulties and whiteout conditions in some areas with gusty winds developing around the storm system.More news: Neymar Injury Gives Liverpool Potential Good News Ahead Of Champions League Showdown
Kluber predicted rain will give way to heavy snowfall and "near whiteout conditions" that will make for unsafe travel.