They've followed it up by losing twice at home to their bitterest rivals Barcelona in the space of just four days, a pair of results that brought to an end Madrid's hopes of domestic silverware this season.
The former Tottenham player has popped up relentlessly in the tabloids over the course of the last weeks with stories rife of him failing to learn the language and, even worse, keep poor old Marcelo company in the dressing room. It lasted two minutes, as Lasse Schone sent a bending free-kick into the top corner before Nacho was sent off late on.
The cheers stopped as referee Felix Brych waited for VAR, with the ball appearing to have gone out for a throw before Noussair Mazraoui slid to keep it in.
Ajax is leaning into the perceived (if a little unfair) narrative that Real Madrid is a juggernaut who spends millions to make its super team, while little Ajax must develop youth players if they want to hang with the big boys.More news: Indiana Basketball keeps hopes of making NCAA Tournament alive
Welsh forward Gareth Bale has endured a mixed spell in the Spanish capital, finding trophies, injuries and criticism in equal measure. A defeat such as the 4-1 thrashing handed out by Ajax, as well as the "shi**y season" as Dani Carvajal labelled it, should serve as a turning point.
Goal! Hakim Ziyech latches onto a Tadic cut back and finds the bottom corner!
"It's a changing period for Real Madrid".
The inspired Tadic turned provider again 10 minutes later, playing in David Neres, who finished coolly from inside the box to put his team 2-0 up on the night.More news: Luke Perry suffers a massive stroke and is recovering in the hospital
Los Blancos are in the building!
Good evening! Welcome to the Live Updates of Real Madrid Vs Ajax in the Champions League.
For the past three years Real Madrid have looked nearly unbeatable in the Champions League as they won Europe's premier club competition for the 11th, 12th and 13th times in their history.More news: Venezuelan security officials sanctioned by US
Ajax started with an unchanged side from the opening leg, with Frenkie de Jong set to play at the Santiago Bernabeu for the first time.